Joey Bishop died yesterday. He was the last surviving member of the Rat Pack.
Some other famous "lasts":
Ray Bolger, who played the Scarecrow, was the last surviving main cast member from the Wizard of Oz. He died in 1987. (However, Meinhardt Raabe, who played the Munchkin coroner, is still alive.)
Tommy Ramone is the only surviving member of the Ramones' orginal lineup.
It remains to be seen who will be the last surviving member of the Beatles or the Who -- both groups have two members remaining.
Twelve men have walked on the moon, three of whom are now deceased. Since all of them were born between 1923 and 1935, I suppose that means that sometime perhaps about a decade and a half from now, there will be a last surviving moon-walker.